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Title of article :
Independent synthesis of aminophospholipid-linked Maillard products Original Research Article
Author/Authors :
Carmen M. Utzmann، نويسنده , , Markus O. Lederer، نويسنده ,
Issue Information :
دوهفته نامه با شماره پیاپی سال 2000
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Abstract :
Phospholipid-linked glycation products are supposed to play an important role in lipid oxidation in vivo. Independent syntheses and unequivocal structural characterization are reported for the phosphatidyl ethanolamine (PE)-derived Amadori compound 4-hydroxy-4-oxo-1-[(palmitoyloxy)methyl]-9-(2,3,4,5-tetrahydroxytetrahydro-2H-pyran-2-yl)-3,5-dioxa-8-aza-4λ5-phosphanon-1-yl palmitate, pyrrolecarbaldehyde 2-{[{2-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]ethoxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl palmitate, the carboxymethyl (CM) derivative 7-hydroxy-7,13-dioxo-10-(palmitoyloxy)-6,8,12-trioxa-3-aza-7λ5-phosphaoctacosan-1-oic acid, and the carboxyethyl (CE) derivative 7-hydroxy-2-methyl-7,13-dioxo-10-(palmitoyloxy)-6,8,12-trioxa-3-aza-7λ5-phosphaoctacosan-1-oic acid. With these reference compounds, a liquid chromatography–mass spectrometry (LCMS) method for the determination of such PE-linked Maillard products has been developed.
Keywords :
Maillard reaction , Glycation , Phosphatidyl ethanolamine , Amadori compound , Advanced glycation endproducts (AGEs)
Journal title :
Carbohydrate Research
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