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Title of article :
Isolation and Characterization of High-Temperature-Induced Dauer Formation Mutants in Caenorhabditis elegans
Author/Authors :
Ailion، Michael نويسنده , , Thomas، James H. نويسنده ,
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روزنامه با شماره پیاپی سال 2003
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Abstract :
Dauer formation in Caenorhabditis elegans is regulated by at least three signaling pathways, including an insulin receptorsignaling pathway. These pathways were defined by mutants that form dauers constitutively (Daf-c) at 25. Screens for Daf-c mutants at 25 have probably been saturated, but failed to identify all the components involved in regulating dauer formation. Here we screen for Daf-c mutants at 27, a more strongly dauer-inducing condition. Mutations identified include novel classes of alleles for three known genes and alleles defining at least seven new genes, hid-1–hid-7. Many of the genes appear to act in the insulin branch of the dauer pathway, including pdk-1, akt-1, aex-6, and hid-1. We also molecularly identify hid-1 and show that it encodes a novel highly conserved putative transmembrane protein expressed in neurons.
Keywords :
Cocos nucifera , waste-grade coir , waste reclamation , peat substitutes , Sustainable Agriculture , container media
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