Record number :
Title of article :
Circulating α-actin in non-insulin-dependent diabetics with autonomic dysfunction
Author/Authors :
Maria José Prados، نويسنده , , Consolacion Melguizo، نويسنده , , Amelia E. Aranega، نويسنده , , Fernando Escobar-Jimenez، نويسنده , , Victoria Cobo، نويسنده , , Rocio Gonzalez-Diaz، نويسنده , , Antonia Aranega، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
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Abstract :
Silent myocardial ischemia in non-insulin-dependent diabetic patients occurs frequently in association with autonomic dysfunction, suggesting that diabetic neuropathy may be involved in the development of this disorder. Repeated episodes of silent myocardial ischemia can induce myocardial necrosis. Recently, actin was detected with Western blotting in the serum of patients with acute myocardial infarction and angina pectoris. We found that a large proportion of non-insulin-dependent diabetic patients with neuropathy also have detectable circulating concentrations of α-actin, and therefore suggest that the determination by immunoblotting of serum α-actin in such patients is an effective method to detect myocardial cell suffering and to identify patients that may need special consideration.
Keywords :
?-Actin , silent myocardial ischemia , Diabetic neuropathy
Journal title :
International Journal of Cardiology
Journal title :
International Journal of Cardiology
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Link To Document :