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Title of article :
3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinoline-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: Chemical synthesis, evaluation in vitro and radiofluorination
Author/Authors :
Uta Funke، نويسنده , , Steffen Fischer، نويسنده , , Achim Hiller، نويسنده , , Matthias Scheunemann، نويسنده , , Winnie Deuther-Conrad، نويسنده , , Peter Brust، نويسنده , , J?rg Steinbach، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
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Abstract :
Aminocyclohexyl indoles bind with high affinity and specificity toward the serotonin transporter (SERT). Based on this structural lead, we designed fluoroalkoxydihydroisoquinoline-cyclohexyl indole carbonitriles for future application as 18F-labeled tracers for SERT imaging by PET. Six compounds, three pairs of cis- and trans-isomer derivatives, respectively, were synthesized and evaluated in vitro. The chemistry of the new compounds, their affinity and specificity data, the general route to the phenolic precursor for labeling, and the successful 18F-fluoroalkylation of one pair of compounds are described herein.
Keywords :
serotonin transporter , PET , Indole carbonitriles , Affinity , Fluorine-18 , Radiolabeling
Journal title :
Bioorganic & Medicinal Chemistry Letters
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