Title of article :
Prevalence of Oral Lichen Planus in HCV+ Patients in Prevalence of Oral Lichen Planus in HCV+ Patients in
قبانچي، ج نويسنده Ghabanchi, J , مالكي، س ر نويسنده Maleki, SR , دقيق افكار، م نويسنده Daghigh Afkar, M
Issue Information :
فصلنامه با شماره پیاپی سال 2009
Background: The association between oral Lichen planus (OLP) as a common oral disease and HCV infection
as an etiological factor in the development of hepatocellular carcinoma has been widely reported. However, there
are wide geographical variations in the reported prevalence. This study was performed to determine the prevalence
of L. planus in HCV+ patients in Shiraz, southern Iran.
Methods: Seventy-six HCV+ positive patients (59 males and 17 females) aged between 28 and 58 years were
enrolled as the case group and 90 HCV-patients (79 males and 11 females) aged between 26 and 62 years
entered the study as the control group. An enzyme linked immunosorbent assay (ELISA) was used to determine
the presence of anti-HCV antibodies in all subjects in both groups. To confirm positive diagnoses, a polymerase
chain reaction test (PCR) was performed. Oral cavity of all patients was clinically examined for the presence of
different types of erosive and keratotic lesions of OLP.
Results: Erosive and keratotic lesions of OLP were detected in buccal mucosa of two cases (2.6%) in the case
group and in one patient of the control group (1.1%).
Conclusion: There was no statistically significant relationship between OLP and HCV infection in Shiraz (P
value=0.57). Further studies are needed to focus on other groups in different regions of Iran to determine whether
testing for HCV infection is necessary in patients with OLP.
Journal title :
Middle East Journal of Digestive Diseases(MEJDD)