Record number :
798798
Title of article :
Conformationally restricted macrocyclic analogues of combretastatins
Author/Authors :
Carmen Mateo، نويسنده , , Raquel ?lvarez، نويسنده , , Concepci?n Pérez-Melero، نويسنده , , Rafael Pelaez Lamamie de Clairac، نويسنده , , Manuel Medarde، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Pages :
5
From page :
6316
To page :
6320
Abstract :
New analogues of combretastatins have been evaluated as inhibitors of tubulin polymerization. These compounds present a macrocyclic structure, in which the para positions of the aromatic moieties have been linked by a 5- or 6-atoms chain, in order to produce a conformational restriction. This could contribute to determine the active conformation for these ligands. Such a conformational restriction and/or the steric hindrance makes them less potent inhibitors than the model compound CA-4.
Keywords :
Macrocycles , Tubulin polymerization inhibition , Combretastatins , Conformational restriction
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2007
Link To Document :
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