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Title of article :
A homology model of SERT based on the LeuTAa template
Author/Authors :
Aina Westrheim Ravna، نويسنده , , Malgorzata Jaronczyk، نويسنده , , Ingebrigt Sylte، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
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Abstract :
A human serotonin transporter (SERT) model has been constructed based on the crystal structure of the bacterial homologue of Na+/Cl−-dependent neurotransmitter transporters from Aquifex aeolicus (LeuTAa). Amino acids in the ligand binding area predicted by ICM pocket finder included Tyr95, Ala96, Asp98, Gly100 (transmembrane helix (TMH) 1), Ala169, Ile172, Ala173, Tyr176 (TMH3), Phe335, Ser336, Gly338, Phe341, Val343 (TMH6), Thr439, Ala441, and Gly442 (TMH8). The present model is an updated working tool for experimental studies on SERT.
Keywords :
The serotonin transporter (SERT) , Homology modeling , template
Journal title :
Bioorganic & Medicinal Chemistry Letters
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