Record number :
794709
Title of article :
Synthesis and structure–activity relationships of 1,5-diazaanthraquinones as antitumour compounds
Author/Authors :
Carmen Avenda?o، نويسنده , , José Mar??a Pérez، نويسنده , , M del Mar Blanco، نويسنده , , Jes?s ?ngel de la Fuente، نويسنده , , Sonia Manzanaro، نويسنده , , Mar??a Jes?s Vicent، نويسنده , , Mar??a Jes?s Mart??n، نويسنده , , Nélida Salvador-Tormo، نويسنده , , J.Carlos Menéndez، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
4
From page :
3929
To page :
3932
Abstract :
1,5-Diazaanthraquinone derivatives were synthesized employing single and double hetero Diels–Alder strategies. Their in vitro antitumour activity was assayed using three cell lines. Some of these compounds, specially those bearing methyl or ethyl groups at the C-3,7 positions or chloro at C-4 and methyl at C-7, showed IC50 values in the 10−8 M range for human lung carcinoma and human melanoma, which makes them attractive candidates for further development as anticancer agents.
Keywords :
Antitumour compounds , Heterocyclic quinones , Solid tumours , Hetero Diels–Alder reactions.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2004
Link To Document :
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