Record number :
792168
Title of article :
Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors
Author/Authors :
Yves St-Denis، نويسنده , , Sophie Lévesque، نويسنده , , Benoit Bachand، نويسنده , , Jeremy J. Edmunds، نويسنده , , Lorraine Leblond، نويسنده , , Patrice Préville، نويسنده , , Micheline Tarazi، نويسنده , , Peter D. Winocour، نويسنده , , M. Arshad Siddiqui، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Pages :
4
From page :
1181
To page :
1184
Abstract :
The potency and selectivity of a previous series of low molecular weight thrombin inhibitors were improved through modifications of the P1 and P3 residues. Introduction of diphenyl substituted sulfonamides in the P3 moiety led to highly efficacious compounds. By correctly selecting the combination of P1 and P3 residues, high levels of potency, selectivity and in vivo efficacy were obtained
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2002
Link To Document :
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