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Title of article :
Regioselective hydrolysis of peracetylated α-D-glucopyranose catalyzed by immobilized lipases in aqueous medium. A facile preparation of useful intermediates for oligosaccharide synthesis
Author/Authors :
Agatha Bastida، نويسنده , , Roberto Fern?ndez-Lafuente، نويسنده , , Gloria Fern?ndez-Lorente، نويسنده , , JoséM. Guis?n، نويسنده , , Giuseppe Pagani and، نويسنده , , Marco Terreni، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Pages :
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Abstract :
Penta-O-acetyl-α-D-Glucopyranose was selectively deacetylated in aqueous media by lipases from Candida cilindracea (CCL) adsorbed on octyl-agarose support. Enzymatic hydrolyses was regioselective at the 4-position under neutral pH and towards the 6 position under acidic conditions. This enzymatic approach allows the one step synthesis of 1,2,3,6-tetra-O-acetyl-α-D-glucopyranoses1, a useful intermediate in oligosaccharide synthesis.
Journal title :
Bioorganic & Medicinal Chemistry Letters
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Link To Document :