Record number :
787666
Title of article :
Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 and Cox-1 inhibitors
Author/Authors :
Yves Leblanc، نويسنده , , JacquesYves Gauthier، نويسنده , , Diane Ethier، نويسنده , , Jocelyne Guay، نويسنده , , Joseph Mancini، نويسنده , , Denis Riendeau، نويسنده , , Philip Tagari، نويسنده , , Philip Vickers، نويسنده , , Elizabeth Wong، نويسنده , , Petpiboon Prasit، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
6
From page :
2123
To page :
2128
Abstract :
A series of 2,3-diarylthiophene compounds was prepared and their biological activities were evaluated against human Cox-1 and Cox-2 enzymes. It appears that the methylsulfone group is essential for both the activity and selectivity for the Cox-2 enzyme. Removal of the methylsulfone group gave relatively selective Cox-1 inhibitors.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
1995
Link To Document :
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