Record number :
787609
Title of article :
4-(2-pyridyl)-2,2-dimethylnaphthalen-1-ones as new potassium channel activators with increased airways selectivity
Author/Authors :
Carmen Almansa، نويسنده , , Luis A. Gomez، نويسنده , , Fernando L. Cavalcanti، نويسنده , , Ricardo Rodriguez، نويسنده , , Juli?n Garc?a-Rafanell، نويسنده , , Javier Forn، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
6
From page :
1833
To page :
1838
Abstract :
A new series of 4-(2-pyridyl)-2,2-dimethylnaphthalen-1-one potassium channel activators has been prepared and their in vitro1 relaxant activities in isolated rat portal vein and guinea-pig tracheal spirals as well as their hypotensive and bronchodilatory effects have been evaluated. Oxidation of the pyridyl nitrogen atom and a double bond between positions 3 and 4 provide compounds with some degree of airways selectivity.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
1995
Link To Document :
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