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Title of article :
A fatal attraction: Mycobacterium tuberculosis and HIV-1 target DC-SIGN to escape immune surveillance
Author/Authors :
Yvette van Kooyk، نويسنده , , Ben Appelmelk، نويسنده , , Teunis B. H. Geijtenbeek، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
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Abstract :
Dendritic cells (DCs) are vital in the defense against pathogens. However, it is becoming increasingly clear that some pathogens subvert DC functions to escape immune surveillance. For example, HIV-1 targets the DC-specific C-type lectin DC-SIGN (DC-specific intercellular-adhesion-molecule-3-grabbing nonintegrin) to hijack DCs for viral dissemination. Binding to DC-SIGN protects HIV-1 from antigen processing and facilitates its transport to lymphoid tissues, where DC-SIGN promotes HIV-1 infection of T cells. Recent studies demonstrate that DC-SIGN is a universal pathogen receptor that also recognizes Ebola, cytomegalovirus and mycobacteria. Mycobacterium tuberculosis targets DC-SIGN by a mechanism that is distinct from that of HIV-1, leading to inhibition of the immunostimulatory function of DC and, hence, promotion of pathogen survival. A better understanding of DC-SIGN–pathogen interactions and their effects on DC function should help to combat infections.
Journal title :
Trends in Molecular Medicine
Journal title :
Trends in Molecular Medicine
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