Record number :
Title of article :
Exploration of different methods for measuring DDT exposure among malaria vector-control workers in Limpopo Province, South Africa
Author/Authors :
Mohamed A. Dalvie، نويسنده , , Jonathan E. Myers، نويسنده , , Mary Lou Thompson، نويسنده , , Thomas G. Robins، نويسنده , , Shaheed Omar، نويسنده , , John Riebow، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
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Abstract :
DDT compounds are used in many developing countries, including South Africa, for the control of malaria vectors. This study investigated biological exposures among workers in relation to job history. A cross-sectional study of 59 workers at the Malaria Control Centre (MCC) in Tzaneen, South Africa, was performed. Tests included a job history questionnaire and the measurement of serum o′p′ and p′p′ isomers of DDE, DDT, and DDD, corrected for serum total lipids. Forty-seven (80%) workers donated a blood sample for the determination of serum DDT. The mean number of years worked at the MCC (malaria years) was 15.8±7.8 years and the mean serum DDT was 94.3±57.1 μg/g of lipid. There were no significant associations between short-to-medium-term serum DDT exposure measures (o′p′-DDE and o′p′ and p′p′ isomers of DDD and DDT) and malaria years. The long-term exposure measure, p′p′-DDE, was significantly associated with malaria years ( μg/g lipid/year; P=0.001; n=47; adjusted for age), but only 27% variance of p′p′-DDE was explained. Blood total DDT uncorrected for lipid content was strongly related to corrected levels ( , P=0.00, R2=0.77), but uncorrected p′p′-DDE had a weaker association ( , P=0.074; R2=0.53) with malaria years than did corrected levels ( ; P=0.016; R2=0.56). The results show that serum DDT levels for malaria vector-control workers in South Africa with a long-term spraying history are high. Job history information on DDT exposures must be very detailed in order to provide valid estimates of exposure.
Keywords :
DDT , Job history , Biological exposures , Developing countries , Malaria vector-control workers
Journal title :
Environmental Research
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