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Title of article :
Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimers disease
Author/Authors :
Cho، Jun Y. نويسنده , , Hwang، Dae Y. نويسنده , , Kang، Tae S. نويسنده , , Shin، Dong H. نويسنده , , Hwang، Jin H. نويسنده , , Lim، Chae H. نويسنده , , Lee، Su H. نويسنده , , Lim، Hwa J. نويسنده , , Min، Sae H. نويسنده , , Seo، Su J. نويسنده , , Song، Youn S. نويسنده , , Nam، Ki T. نويسنده , , Lee، Kyu S. نويسنده , , Cho، Jung S. نويسنده , , Kim، Yong K. نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
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Abstract :
In its late stage, Alzheimerʹs disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice expressing the skeletal muscle-specific mutant PS2 gene (a model of Alzheimerʹs disease) are a useful experimental system to study the protective effect of exercise on A(beta)-42 reduction, improvement of behavioural function and changes in metabolic parameters. With this aim in mind, the transgenic mice were subjected to treadmill exercise for 3 months. The results showed that in transgenic mice, but not in normal mice, treadmill exercise resulted in a reduction of A(beta)-42 deposits and an improvement in behavioural function, thereby restoring normal concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Thus, exercise may represent a practical therapeutic strategy for use with human patients with Alzheimerʹs disease.
Keywords :
sports , presenilin , transgenic , Alzheimers disease , cholesterol , exercise
Journal title :
Journal of Sports Sciences
Journal title :
Journal of Sports Sciences
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