Record number :
671983
Title of article :
Synthesis and Cyclization Reactions with Pyrazolopyrimidinyl Keto-esters and their Enzymaic Activity
Author/Authors :
Mohamed Abdel Hamid Abd el Gawaad Awas، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
10
From page :
492
To page :
501
Abstract :
Ethyl 2,4-dioxo-4-(4-oxo-1-phenyl-1,4-dihydo-5H-pyrazolo3,4-dpyrimidin-5-yl)butanoate, ethyl 5-(4-oxo-1-phenyl- 1,4-dihydro-5H-pyrazolo{3,4-d}pyrimidin-5-yl)-1H-pyrazole-3-carboxylate and their acid hydrazide derivatives have been prepared and reacted with hydrazines, ortho-phenylenediamine, triethyl orthoformate, carbon disulfide and thiosemicarbazides in order to obtain some new 5-substituted pyrazolopyrimidin-4-ones as pyrazolines, isoxazolines, imidazoles, pyrazolotriazines, thiadiazoles and triazoles. All newly prepared compounds revealed the potent effect on increasing reactivity of cellobiase. Structures of new compounds were established upon their elemental analysis, IR, 1H NMR and mass fragmentation spectra.
Keywords :
Pyrazolines , isoxazolines , Imidazoles , pyrazolotriazines , thiadiazoles and triazoles
Journal title :
Acta Chimica Slovenica
Link To Document :