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Title of article :
Non-alcoholic fatty liver disease in an area of southern Italy: main clinical, histological, and pathophysiological aspects
Author/Authors :
Carmela Loguercio، نويسنده , , Vincenzo De Girolamo، نويسنده , , Ilario de Sio، نويسنده , , Concetta Tuccillo، نويسنده , , Antonio Ascione، نويسنده , , Feliciano Baldi، نويسنده , , Gabriele Budillon، نويسنده , , Lucia Cimino، نويسنده , , Antonio Di Carlo، نويسنده , , Maria Pia Di Marino، نويسنده , , Filomena Morisco، نويسنده , , Francesco Picciotto، نويسنده , , Luigi Terracciano، نويسنده , , Raffaella Vecchione، نويسنده , , Veronica Verde، نويسنده , , Camillo Del Vecchio Blanco، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
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Abstract :
Background/Aims: Studies on non-alcoholic fatty liver disease (NAFLD) have included chronic liver damage attributed to various causes. Our investigation was held to observe the main clinical, histological, and pathophysiological aspects of NAFLD in patients not exposed to any known cause of chronic liver disease. Methods: We evaluated, in 84 in-patients (male/female, 66/18; median age, 36 years), the clinical and biochemical characteristics of NAFLD, and particularly its association with diabetes, dyslipidemia, hyperinsulinemia and/or with the increase of parameters of oxidative stress (blood levels of malonyldialdehyde, 4-hydroxynonenal and total plasma antioxidant capacity). Results: Ninety percent of patients had an increased body mass index (BMI), 35% had dyslipidemia, 40% had sub-clinical diabetes (only 3% had overt diabetes), 60% had hyperinsulinemia, and more than 90% had enhanced levels of lipid peroxidation markers. In 48 patients who had consented to liver biopsy, we found: 14 with simple steatosis, 32 with steatohepatitis, and two with cirrhosis. Conclusions: Our data indicate that in our country, NAFLD may occur in young males with an increased BMI, with or without hyperinsulinemia, dyslipidemia and diabetes, generally associated with disorders of redox status, and that it may be differentiated from steatosis to steatohepatitis or cirrhosis only with a liver biopsy.
Keywords :
Liver steatosis , Non-alcoholic fatty liver disease , Steatohepatitis
Journal title :
Journal of Hepatology
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