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Title of article :
Alpha-glutathione transferases in HCV-related chronic hepatitis: a new predictive index of response to interferon therapy?
Author/Authors :
Carmela Loguercio، نويسنده , , Nicola Caporaso، نويسنده , , Concetta Tuccillo، نويسنده , , Filomena Morisco، نويسنده , , Giovanna Del Vecchio Blanco، نويسنده , , Camillo Del Vecchio Blanco، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
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Abstract :
Background/Aim: The aim of this study was to evaluate if plasma levels of alpha-glutathione-S-transferases (determined in basal conditions and monthly for 1 year during and 1 year after interferon therapy) could characterize patients who show only a primary response. Methods: We studied 48 patients with biopsy-proven, hepatitis C virus ribonucleic acid positive chronic hepatitis treated with interferon: 18 were “Sustained Responders”, 12 “Relapsers” and 18 “Non-Responders”. Results: Relapsers showed higher basal levels of alpha-glutathione-S-transferases, which remained higher than normal even when alanine aminotransferases normalized. No correlation was documented between alpha-glutathione-S-transferase levels and all other parameters examined (alanine aminotransferases, γ-glutamyl-transpeptidase, viremia, and histological activity index). Conclusions: These findings suggest that alpha-glutathione-S-transferase levels may be considered a predictive index of response to interferon therapy in chronic hepatitis C patients.
Keywords :
Alpha-glutathione-transferases , interferon. , HepatitisC
Journal title :
Journal of Hepatology
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