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Title of article :
Iron and the liver: Update 2008
Author/Authors :
Yves Deugnier، نويسنده , , Pierre Brissot، نويسنده , , Olivier Loreal ، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
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Abstract :
The cross-talk which has taken place in recent years between clinicians and scientists has resulted in a greater understanding of iron metabolism with the discovery of new iron-related genes including the hepcidin gene which plays a critical role in regulating systemic iron homeostasis. Consequently, the distinction between (a) genetic iron-overload disorders including haemochromatosis related to mutations in the HFE, hemojuvelin, transferrin receptor 2 and hepcidin genes and (b) non-haemochromatotic conditions related to mutations in the ferroportin, ceruloplasmin, transferrin and di-metal transporter 1 genes, and (c) acquired iron-overload syndromes has become easier. However, major challenges still remain which include our understanding of the regulation of hepcidin production, the identification of environmental and genetic modifiers of iron burden and organ damage in iron-overload syndromes, especially HFE haemochromatosis, indications regarding the new oral chelator, deferasirox, and the development of new therapeutic tools interacting with the regulation of iron metabolism.
Keywords :
Haemochromatosis , Hepatic iron-overload , Iron metabolism
Journal title :
Journal of Hepatology
Journal title :
Journal of Hepatology
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