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Title of article :
Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake
Author/Authors :
Bernardo L. Trigatti، نويسنده , , AttilioRigotti، نويسنده , , Anne Braun، نويسنده ,
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Abstract :
High-density lipoproteins (HDL) play an important role in protection against atherosclerosis by mediating reverse cholesterol transport – the transport of excess cholesterol from peripheral tissues to the liver for disposal. SR-BI is a cell surface receptor for HDL and other lipoproteins (LDL and VLDL) and mediates the selective uptake of lipoprotein cholesterol by cells. Overexpression or genetic ablation of SR-BI in mice revealed that it plays an important role in HDL metabolism and reverse cholesterol transport and protects against atherosclerosis in mouse models of the disease. If it plays a similar role in humans then it may be an attractive target for therapeutic intervention. We will review some of the recent advances in the understanding of SR-BI’s physiological role and cellular function in lipoprotein metabolism
Keywords :
Scavenger receptor class B , high density lipoprotein , low density lipoprotein , atherosclerosis , apoA-I , type I , reverse cholesterol transport
Journal title :
Astroparticle Physics
Link To Document :