Record number :
558472
Title of article :
Effectiveness of meningococcal C conjugate vaccine in teenagers in England
Author/Authors :
Anuradha Bose، نويسنده , , Pietro Coen، نويسنده , , Joanna Tully، نويسنده , , Russell Viner and David W. Rice، نويسنده , , Robert Booy، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
2
From page :
675
To page :
676
Abstract :
Meningococcal C conjugate vaccine was introduced into clinical practice in the UK before phase 3 trials had been undertaken. We therefore did a case-control study in teenagers to assess vaccine effectiveness. All cases (n=31) enrolled had laboratory confirmed meningococcal C disease. We also enrolled between one and three controls (n=65) per case, matched by age, sex, and general practitioner. Three patients and 23 controls had been vaccinated. The protective effectiveness of the vaccine, estimated by conditional logistic regression, was 93% (95% CI 39–99), which is similar to screening method estimates. The estimated protective effectiveness varied little when potential confounding risk factors were taken into account. Our findings indicate that the vaccine is highly protective against invasive meningococcal C disease.
Journal title :
The Lancet
Serial Year :
2003
Link To Document :
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