Record number :
558368
Title of article :
Large-scale evidence that the cardiotoxicity of smoking is not significantly modified by the apolipoprotein E ε2/ε3/ε4 genotype
Author/Authors :
Bernard Keavney، نويسنده , , Sarah Parish، نويسنده , , Alison Palmer، نويسنده , , Sarah Clark، نويسنده , , Linda Youngman، نويسنده , , John Danesh، نويسنده , , Colin McKenzie، نويسنده , , Marc Delépine، نويسنده , , Mark Lathrop، نويسنده , , Richard Peto، نويسنده , , Rory Collins and for the international Studies of Infarct Survival (ISIS) Collaborators، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
3
From page :
396
To page :
398
Abstract :
Results from two small studies, involving a total of only 174 cases, have suggested that the increased risk of coronary heart disease conferred by cigarette smoking is substantially affected by genotype at the apolipoprotein E (APOE) ε2/ε3/ε4 polymorphism. We have established APOE genotypes in 4484 patients with acute myocardial infarction diagnosed before the age of 55 years for male and 65 years for female patients, and in 5757 controls with no history of cardiovascular disease. On average, the hazard ratio for myocardial infarction was 1•17 (95% CI 1•09–1•25; p<0•00001) per stepwise change from ε3/2 to ε3/3 to ε3/4 genotype. Among individuals in this study with known cigarette smoking status, the hazard ratio for myocardial infarction in smokers versus non-smokers was 4•6 (4•2–5•1). There was, however, no significant difference between the smoker/non-smoker hazard ratios for those with different APOE genotypes (χ22=0•69; p=0•7). When differences in risk between different genotypes are not extreme (as with this APOE polymorphism), reliable assessment of hypothesised gene-environment interactions will often require the study of many thousands of disease cases.
Journal title :
The Lancet
Serial Year :
2003
Link To Document :
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