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Title of article :
Angiographic methods to assess human coronary angiogenesis
Author/Authors :
C.Michael Gibson، نويسنده , , Kathryn Ryan، نويسنده , , Anthony Sparano، نويسنده , , John L. Moynihan، نويسنده , , Michael Rizzo، نويسنده , , Michael Kelley، نويسنده , , Susan J. Marble، نويسنده , , Roger Laham، نويسنده , , Michael Simons، نويسنده , , Theodore R. McClusky، نويسنده , , J.Theodore Dodge Jr، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
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Abstract :
It is unclear how agents designed to promote angiogenesis in the human heart affect the arteriographic appearance of the collateral circulation. Possible changes in collateral vessels include new collateral vessels arising from epicardial arteries, new branches emanating from existing collateral vessels, wider or longer collateral vessels, and higher dye transit rates that result in improved recipient vessel filling. Given the multiple mechanisms by which these new agents may improve myocardial perfusion, a rigorous, systematic, and comprehensive analysis of coronary arteriograms is required to discern the true mechanism of benefit. The method of analysis must account for potential changes in collateral blood flow, number, branching pattern, and length as well as changes in recipient vessel filling. The ability to detect differences between intricate networks of vessels in an angiographic study is dependent on maintaining consistency in cinefilming as well as the core laboratory methods between time points. In this report, we describe the methodology our angiographic core laboratory has found to be most effective to evaluate these very complex angiograms and attempt to capture all the possible modalities of angiogenesis. (Am Heart J 1999;137:169-79.)
Journal title :
American Heart Journal
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