Record number :
530965
Title of article :
Relation between injections before 90-minute angiography and coronary patency: Results of the Thrombolysis in Myocardial Infarction 4 Trial*, , , ,
Author/Authors :
C.Michael Gibson، نويسنده , , Susan J. Marble، نويسنده , , Michael J. Rizzo، نويسنده , , John Moynihan، نويسنده , , Christine McLean، نويسنده , , Kathryn Ryan، نويسنده , , Anthony Sparano، نويسنده , , Robert N. Piana، نويسنده , , Carolyn McCabe، نويسنده , , Christopher P. Cannon، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Pages :
4
From page :
351
To page :
354
Abstract :
The current goal of thrombolytic therapy is to achieve both full (Thrombolysis in Myocardial Infarction [TIMI] grade 3) and early reperfusion. Newer reperfusion strategies may now achieve a high degree of reperfusion even earlier than the traditional 90-minute end point. To determine whether injections before 90 minutes affect this traditional end point, the relation between the number of injections before 90-minute angiography and patency was examined in the TIMI 4 trial. The number of injections before 90-minute angiography was no different between occluded arteries (TIMI grade 0/1 flow) (2.46 ± 1.78; n = 94) and patent arteries (TIMI grade 2/3 flow) (2.71 ± 2.42; n = 295) (p = 0.24). The incidence of any injections before 90 minutes was no different in patent versus closed arteries (80.6% [77/98] vs 72.4% [22/304]; p = 0.10). The number of injections before 90 minutes was insignificantly smaller in patients with TIMI grade 3 flow (2.53 ± 2.53 [n = 184] vs 2.76 ± 2.03 [n = 204]; p = 0.31) but the incidence of any injections before 90 minutes was significantly smaller in patients with TIMI grade 3 flow (68.8% [132/192] vs 79.5% [167/210]; p = 0.01). No relation was identified between the number of injections before 90-minute angiography and patency at this traditional time point. This observation justifies the judicious use of a limited number of “earlier snapshots” of the infarct-related artery before 90 minutes to ascertain just how rapidly newer thrombolytic regimens achieve patency. Patients with TIMI grade 3 flow had a slightly lower incidence of injections before 90 minutes, perhaps because they did not require as urgent a definition of coronary anatomy. (Am Heart J 1997;134:351-4.)
Journal title :
American Heart Journal
Serial Year :
1997
Link To Document :
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