Title of article :
Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation
Carsten B Schmidt-Weber، نويسنده , , Kurt Blaser، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Transforming growth factor-β (TGF-β) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-β in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-β in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-β; however, TGF-β-mediated tissue remodelling can be a serious complication in such diseases.
Journal title :
Current Opinion in Immunology