Title of article :
Signal transduction by the TCR for antigen
Lawrence P. Kane، نويسنده , , Fuchun Joseph Lin، نويسنده , , Arthur Weiss، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
The past several years have seen the beginning of a shift in the way that TCR signal transduction is studied. Although many investigators continue to identify new molecules, particularly adaptor proteins, others have attempted to look at signaling events in a larger cellular context. Thus the identification of distinct formations of signaling molecules at junctions between T cells and antigen-presenting cells, the role of the cytoskeleton and the partitioning of molecules into specialized lipid subdomains have been the subjects of many publications. Such concepts are helping to assemble a blueprint of how the myriad adaptors and kinases fit together to effect T cell activation.
Journal title :
Current Opinion in Immunology