Title of article :
Recognition events that inhibit and activate natural killer cells
David H Raulet، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Natural killer (NK) cells exhibit specificity for MHC class I molecules in their interactions with target cells. Instead of activating the cells, the recognition of class I molecules on target cells inhibits NK-cell lytic ctivity, suggesting that surveillance of normal class I expression by body cells represents a key NK-cell function. Recent advances have been made in identification of the class I specific receptors expressed by NK cells, and in the characterization of their detailed specificity and expression patterns. Other studies are beginning to unravel recognition events that activate NK cells.
Journal title :
Current Opinion in Immunology