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Title of article :
Neural and Behavioral Plasticity Associated with the Transition from Controlled to Escalated Cocaine Use
Author/Authors :
Carrie R. Ferrario، نويسنده , , Grazyna Gorny، نويسنده , , Hans S. Crombag، نويسنده , , Yilin Li، نويسنده , , Bryan Kolb، نويسنده , , Terry E. Robinson، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
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Abstract :
Background Rats given extended access to cocaine develop several symptoms of addiction, including a gradual escalation of drug intake, whereas rats given limited access do not. We asked here whether extended access to cocaine also produces drug-induced sensitization, a form of neurobehavioral plasticity implicated in addiction. Methods Rats were given limited (1 hour/session) or extended access (6 hours/session) to self-administered cocaine. Following a period of abstinence, rats were selected at random for assessment of their psychomotor response to cocaine or drug-seeking during extinction or for anatomic studies. Results When reexposed to cocaine, rats allowed extended drug access showed greater drug-seeking behavior and were hypersensitive (sensitized) to the psychomotor activating effects of cocaine compared with rats given limited access. Extended access to cocaine was also associated with a greater increase in the density of dendritic spines on neurons specifically in the core of the nucleus accumbens (and not in the shell or medial or orbital frontal cortex). Conclusions The transition from stable to escalated cocaine use, a hallmark of addiction, is associated with especially robust behavioral sensitization and synaptic reorganization in the core of the nucleus accumbens.
Keywords :
prefrontalcortex , sensitization , Addiction , dendritic spines , Nucleus accumbens , structural plasticity
Journal title :
Biological Psychiatry
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