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Title of article :
The Ala-9Val polymorphism in the mitochondrial targeting sequence (MTS) of the manganese superoxide dismutase gene is not associated with juvenile-onset asthma
Author/Authors :
Ahmet Gürel، نويسنده , , Nazan Tomac، نويسنده , , H. Ramazan Yilmaz، نويسنده , , Ibrahim Tekedereli، نويسنده , , Omer Akyol، نويسنده , , Ferah Armutcu، نويسنده , , Huseyin Yuce، نويسنده , , Haluk Akin، نويسنده , , Nurten Ozcelik، نويسنده , , Halit Elyas، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
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Abstract :
Background: We aimed to investigate the possible association between Mn-SOD polymorphism in the mitochondrial targeting sequence and asthma. Methods: Alanine or valine polymorphism in the signal peptide of Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with NgoM IV. Results: No significant difference in genotype frequencies was found between patients and controls. Conclusion: These results suggest no major modifying role for the Mn-SOD gene polymorphism in patients with asthma.
Keywords :
asthma , polymorphism , oxidative stress , manganese superoxide dismutase
Journal title :
Clinical Biochemistry
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Link To Document :