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Title of article :
Ligation errors in DNA computing
Author/Authors :
Aoi، Yohei نويسنده , , Yoshinobu، Tatsuo نويسنده , , Tanizawa، Katsuyuki نويسنده , , Kinoshita، Kozo نويسنده , , Iwasaki، Hiroshi نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
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Abstract :
DNA computing is a novel method of computing proposed by Adleman (1994), in which the data is encoded in the sequences of oligonucleotides. Massively parallel reactions between oligonucleotides are expected to make it possible to solve huge problems. In this study, reliability of the ligation process employed in the DNA computing is tested by estimating the error rate at which wrong oligonucleotides are ligated. Ligation of wrong oligonucleotides would result in a wrong answer in the DNA computing. The dependence of the error rate on the number of mismatches between oligonucleotides and on the combination of bases is investigated.
Keywords :
steady state , Enzyme systems , Rapid equilibrium , Kinetic equations , Computer program , Transient phase
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