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Title of article :
Hematopoietic stem cell transplantation (HSCT): An approach to autoimmunity
Author/Authors :
Carmen Alaez، نويسنده , , Mariana Loyola، نويسنده , , Andrea Murgu?a، نويسنده , , Hilario Flores، نويسنده , , Araceli Rodr?guez، نويسنده , , Roberto Ovilla، نويسنده , , Gregorio Ignacio، نويسنده , , Raquel Amador، نويسنده , , Victor Salinas، نويسنده , , Fernanda Perez، نويسنده , , Danaee Rodr?guez، نويسنده , , Zoila Morales، نويسنده , , Gonzalo Llinguin، نويسنده , , Alejandra Vazquez، نويسنده , , Analia Altamirano، نويسنده , , Clara Gorodezky، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
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Abstract :
HSCT provides the opportunity to replace a damaged tissue. It is the most important treatment for high risk hematologic malignant and non malignant disorders. An important challenge in the identification of matched donors/patients is the HLA diversity. The Mexican Bone Marrow Registry (DONORMO) has nowadays > 5000 donors. The prevalent alleles are Amerindian, Mediterranean (Semitic and Spanish genes) and African. In theory, it is possible to find 11% of 6/6 A–B–DR low resolution matches for 70% of patients with Mexican ancestry. We contributed with 39 unrelated, cord blood and autologous HSCT for patients with malignant, genetic and autoimmune disorders. Overall disease survival was 50% (2–7 years) depending on the initial diagnosis, conditioning, disease evolution or other factors. Clinical studies using autologous and unrelated HSC are performed on patients with refractory autoimmune diseases producing mixed results: mainly, T1D, RA, MS, SLE. Improvement has been observed in skin damage and quality of life in SLE and systemic sclerosis. Disease stabilization in 2/3 of MS patients. However, in RA and T1D, initial benefits have been followed by eventual relapse. With growing clinical experience and protocol improvement, treatment-related mortality is decreasing. Proof efficacy will be achieved by comparing HSCT with standard therapy in autoimmunity.
Keywords :
HLA , MHC , allogeneic , autologous , Hematopoietic stem cell transplantation (HSCT) , Autoimmune diseases (AD) , Unrelated HSCT
Journal title :
Autoimmunity Reviews
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