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Title of article :
The veterinary experience
Author/Authors :
Yves Moens، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
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Abstract :
Veterinarians have three decades of experience with the use of α2-agonists. Xylazine, synthesized in 1962, was the first α2-agonist to be used as a sedative and analgesic, first in cattle and later in many other species. The major side-effects were bradycardia and a biphasic blood pressure response with moderate hypotension following an initial hypertensive episode. In the 1980s, new α2-agonists with a much higher potency and greater specificity at central α2-adrenoceptor sites were introduced: detomidine, romifidine and medetomidine. These drugs showed side-effects similar to those of xylazine but had a longer sedative and analgesic action. Alpha2-agonists have proved to be safe agents for analgo-sedation and muscle relaxation in healthy animals. In combination with opioids or mono-anaesthetics, they can be used either to induce a profound sedative-analgesic state or to enhance general anaesthesia while reducing the anaesthetic requirement and smoothing the recovery phase. The availability of α2-antagonists such as atipamezole has increased safety and allowed remarkable versatility in veterinary anaesthetic management.
Keywords :
animals , Xylazine , sedation , a2-adrenoceptor agonist , a2-adrenoceptor antagonist , veterinarymedicine , detomidine , romi®dine , medetomidine.
Journal title :
Best Practice and Research Clinical Anaesthesiology
Journal title :
Best Practice and Research Clinical Anaesthesiology
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