Record number :
29571
Title of article :
Synthesis and biological evaluation of 1-(4-[18f]fluorobenzyl)-4-[(5,6-dimethoxy-1-oxoindan2-yl)methyl]piperidine for in vivo studies of acetylcholinesterase
Author/Authors :
Choe، Yearn Seong نويسنده , , Kim، Sang Eun نويسنده , , Lee، Kyung-Han نويسنده , , Choi، Yong نويسنده , , Kim، Byung-Tae نويسنده , , Leea، Sang-Yoon نويسنده , , Sugimoto، Hachiro نويسنده , , Hwang، Sae Hwan نويسنده , , Lee، Jeewoo نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
-740
From page :
741
To page :
0
Abstract :
The muscarinic cholinergic receptor ligands N-[11C]ethyl-4-piperidyl benzilate (4-EPB) and N-[11C]propyl-4-piperidyl benzilate (4-PPB) were developed and evaluated in comparison with N-[11C]methyl-4-piperidyl benzilate (4-MPB) in the conscious monkey brain using positron emission tomography (PET). Time-activity curves of [11C]4-EPB, unlike [11C]4MPB, showed peaks within 91 min in regions rich in muscarinic receptors. [11C]4-PPB showed no specific binding even in the regions rich in these receptors. These observation demonstrated that increases in [11C]alkyl chain length could alter the kinetic properties of receptor ligands for PET.
Keywords :
Acetylcholinesterase , 18F , Alzheimers disease , 4-fluorodonepezil
Journal title :
NUCLEAR MEDICING & BIOLOGY
Journal title :
NUCLEAR MEDICING & BIOLOGY
Serial Year :
2000
Link To Document :
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