Record number :
2616475
Title of article :
Comparative evaluation of oncologic outcomes in colon cancer
Author/Authors :
Bernardes, Mário Vinícius Angelete Alvarez Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil , Feitosa, Marley Ribeiro Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil , Peria, Fernanda Maris Ribeirão Preto Medical School - University of São Paulo, Brazil , Tirapelli, Daniela Pretti da Cunha Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil , Rocha, José Joaquim Ribeiro da Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil , Feres, Omar Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil
Pages :
6
From page :
34
To page :
39
Abstract :
PURPOSE: In this paper we report clinical variables on colon cancer series. Oncological outcomes were compared to low-income and high-income countries. METHODS: We analysed a prospective database of 51 colon cancer patients submitted to primary tumor resection between 2010 and 2011, showing clinical variables and oncologic outcomes. RESULTS: R0 resection obtained in 80.4%, 21.6% of patients was TNM stage IV, and only 13.7% showed TNM stage I. Disease-free survival was 32 months, overall survival was 46 months, and the tumoral recurrence rate was 9.8%. Univariate analysis showed association of serum CEA levels ≥ 5 ng/dl (p= 0.004), presence of metastasis at diagnosis (p= 0.012), compromised surgical margins (p < 0.001) and poorer tumor differentiation (p= 0.041) to death. Multivariate analysis identified compromised surgical margins as an independent risk factor for death due to colon cancer (P=0.003; odds ratio=0.36; 95% confidence interval=0.004-0.33). Nowadays, 62.7% of patients are alive. CONCLUSION: Recurrence rate, disease-free survival and overall survival was similar to those observed in more developed countries. Serum CEA levels ≥ 5 ng/dl, the presence of metastasis at diagnosis, compromised surgical margins and poorer tumor differentiation were associated with death. A compromised surgical margin was the only independent risk factor for death.
Keywords :
Colonic Neoplasms , Colon , Drug Therapy , Disease-Free Survival , Survival
Journal title :
Acta Cirurgica Brasileira
Serial Year :
2016
Full Text URL :
Link To Document :
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