Bangar, Megha Department of Biochemistry - Seth G.S. Medical College and K.E.M Hospital - Parel, Mumbai, India , Khillare, Supriya Department of Biochemistry - Seth G.S. Medical College and K.E.M Hospital - Parel, Mumbai, India , Chalak, Anita Department of Biochemistry - Seth G.S. Medical College and K.E.M Hospital - Parel, Mumbai, India , Maksane, Shalini Department of Biochemistry - Seth G.S. Medical College and K.E.M Hospital - Parel, Mumbai, India
Introduction: Novel coronavirus disease 2019 (COVID-19) has become a global public health
calamity since its outbreak in Wuhan, China in December 2019, and there is a lack of diagnostic
biochemical data related to the disease. This study aimed to investigate routine biochemical
parameters in COVID-19 positive Indian patients and check their predictive value for the
detection of this novel disease.
Materials and Methods: This observational study was conducted retrospectively with the
participation of 166 patients referred to King Edward Memorial (KEM) Hospital, Mumbai,
India during May 2020. The baseline characteristics (age and gender) and biochemical data of
individuals with COVID-19-related symptoms but negative for COVID-19 were collected and
classified into two groups of real-time reverse transcriptase polymerase chain reaction (RT-PCR)
and COVID-19 positive. The value of organ function tests (blood urea nitrogen [BUN], creatinine,
and levels of serum electrolytes, alanine aminotransferase [ALT], aspartate aminotransferase
(AST), bilirubin total, bilirubin direct, total protein, and albumin) were noted and analyzed.
The groups were compared using unpaired t test, and predictive value of these parameters for
COVID-19 was evaluated by calculating the area under the ROC curve (AUC).
Results: There was a significant rise in the serum AST ALT, bilirubin direct, BUN, and creatinine
levels of COVID-19 subjects compared to non-COVID-19 ones (P < 0.001). AST (AUC=0.826,
CI: 0.76 to 0.89, P < 0.001), ALT (AUC=0.8525, 95% CI: 0.79 to 0.90, P < 0.001), and BUN
(AUC=0.8097, 95% CI: 0.74 to 0.87, P < 0.001) showed very good accuracy and serum
creatinine (AUC=0.7971, 95% CI: 0.73 to 0.86, P < 0.001) showed good accuracy in predicting
COVID- 19 positivity.
Conclusion: Serum levels of ALT, AST, BUN, and creatinine can be the reliable predictors of
COVID-19 test and identify infected patients.
COVID-19 , Liver function test , Kidney function test , Biochemical parameters