Record number :
2523280
Title of article :
Glaucomatous Macular Vasculature: A Quantitative Analysis
Author/Authors :
Arede, Pedro Ophthalmology Department of Egas Moniz Hospital - Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal , Przezdziecka-Dolyk, Joanna Department of Optics and Photonics - Wrocław University of Science and Technology, Poland , Debowy, Fabian Department of Optics and Photonics - Wrocław University of Science and Technology, Poland , Olszewski, Jacek Department of Optics and Photonics - Wrocław University of Science and Technology, Poland , Fernandes, Carla Ophthalmology Department of Egas Moniz Hospital - Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal , Bruxelas, Carolina Ophthalmology Department of Egas Moniz Hospital - Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal , Spohr, Helena Ophthalmology Department of Egas Moniz Hospital - Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal , Patricio, Sara Ophthalmology Department of Egas Moniz Hospital - Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal
Pages :
13
From page :
185
To page :
197
Abstract :
Background: The aim of this study was to evaluate the characteristics of the macular vessel density (VD) and the foveal avascular zone (FAZ) in glaucoma quantitatively using the optical coherence tomography angiography (OCT-A). Methods: Twenty-five eyes of 13 patients with primary open angle glaucoma (POAG) and 12 eyes of 6 healthy participants were enrolled retrospectively. Functional visual field (VF) and structural Spectral-Domain optical coherence tomography (SD-OCT) Retinal Nerve Fiber Layer Thickness (RNFLT) were assessed in all participants. OCT-A was performed on a fovea centered, 15x10 degrees, macular region. OCT-A scans were processed with MATLAB software and automatically graded to define FAZ parameters. The parafoveal VD in the superficial and deep retinal vascular plexus (SVP and DVP) was analyzed by quadrant and circular segmented zones. Results: Foveal Avascular Zone -Major Axis Length (p=0.02), Area (p=0.04), Equivalent Diameter (p=0.04) and Perimeter (p=0.04) were significantly larger in glaucoma than the control group. Regarding SVP and DVP, the average macular total VD were lower in glaucoma patients compared to the control group (p<0.01; p<0.01). Additionally, the inner circular region (p=0.04; p<0.01 respectively for SVP and DVP) and all quadrants except for North had a lower VD in glaucoma group compared to the control group. Assessment of the total VD successfully predicted RNFLT (p<0.001) and was significantly associated with the probability of glaucoma (p=0.009). Conclusions: OCT-A parameters, namely the FAZ morphology and the macular VD, were associated with glaucomatous functional and structural changes. The macular VD showed a considerable diagnostic value. It may be a modern biomarker, representing microvascular network disruption of the macular perfusion in glaucoma.
Keywords :
Glaucoma , OCT-A , Vascular Dropout , Macular Vessel Density , Foveal Avascular Zone , Biometry , Optical Coherence Tomography Angiography , Biomarker , Macular Perfusion , Superficial Vascular Plexus , Deep Vascular Plexus
Journal title :
Medical Hypothesis, Discovery & Innovation Ophthalmology
Serial Year :
2020
Link To Document :
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