Record number :
2482580
Title of article :
Study of Anti Cancer Property of Scrophularia striata Extract on the Human Astrocytoma Cell Line (1321)
Author/Authors :
Ardeshiry lajimi, Abdulreza Proteomics Research Center (PRC) - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran , Rezaie-Tavirani, Mostafa Proteomics Research Center (PRC) - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran , Mortazavi, Alireza Department of Pharmaceutics - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran , Barzegar, Mansoureh Department of Cell and Molecular Biology - Khatam Universiy, Tehran , Moghadamnia, Hasan Proteomics Research Center (PRC) - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran , Rezaee, Mohamad Bagher Institute of Forest and Rangelands, Tehran
Pages :
8
From page :
403
To page :
410
Abstract :
There are considerable efforts to identify naturally occurring substances as new drugs in cancer therapy. Many components of medicinal plants have been identified that possess substantial anticancerous properties. This prompted us to investigate the effect of Scrophularia striata (an Iranian species belonging to the Scrophulariace family) extract on the growth of astrocyte cancer cell line (1321). The 1321 cell line were seeded in 96-well culture plates in the presence and absence of various concentrations of either leaf and seed filtered and unfiltered extract of Scrophularia striata to determine their probable anticancer effects in comparison with etoposide (chemical anticancer reagent). filtered leaf extract of S. Striata showed strong anticancer effect on 1321cell line as compared to control group (cells not exposed to extracts), and even the group (adenocarcinoma gastric cell line) exposed to etoposide. Unlike the leaf extract, the seed extract activated cell proliferation in all experiments. Flow cytometry findings indicated that apoptosis is the mechanism by which the leaf extract inhibits cell proliferation. Our findings indicate that both leaves and seeds of S. Striata contain both anti cancer and cell growth enhancing agents.
Keywords :
Astrocytoma , 1321 cell line , Scrophularia striata extract , Flow cytometry , Anticancer effect
Journal title :
Astroparticle Physics
Serial Year :
2010
Link To Document :
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