Record number :
2471426
Title of article :
The effect of low- dose tranexamic acid on postoperative blood loss in patients treated with clopidogrel and aspirin
Author/Authors :
Banihashem, Nadia Clinical Research Development Unit of Ayatollah Rouhani Hospital - Babol University of Medical Sciences, Babol, Iran , Khorasani, Moghadam Clinical Research Development Unit of Ayatollah Rouhani Hospital - Babol University of Medical Sciences, Babol, Iran , Vaffai, Hamidreza Clinical Research Development Unit of Ayatollah Rouhani Hospital - Babol University of Medical Sciences, Babol, Iran , Naziri, Fereshteh Clinical Research Development Unit of Ayatollah Rouhani Hospital - Babol University of Medical Sciences, Babol, Iran , Khafri, Soraya Infertility and Health Reproductive Research Center - Health Research Institute - Babol University of Medical Sciences, Babol, Iran , Seyfi, Shahram Clinical Research Development Unit of Ayatollah Rouhani Hospital - Babol University of Medical Sciences, Babol, Iran
Pages :
6
From page :
156
To page :
161
Abstract :
Background: Clopidogrel in combination with aspirin increases bleeding, allogeneic red cell transfusion and reoperation rates after CABG. Tranexamic acid, an antifibrinolytic agent, has been approved for use in cardiac surgery to reduce bleeding. In the present study, we evaluated the impact of tranexamic acid on the transfusion and post-operative blood loss after CABG in patients treated with clopidogrel less than 5 days before surgery. Methods: This study was a prospective, randomized, double-blinded clinical trial. Patients undergoing on-pump CABG with their last dose of clopidogrel and aspirin less than 5 days preoperatively were randomly assigned to receive tranexamic acid (10 mg/kg before surgical incision and 10 mg/kg after protamine neutralization) or a corresponding volume of saline solution. The incidence of allogeneic red cell transfusion and 48h postoperative blood loss were recorded. Results: The average volume of blood loss was 776.92±459.81mL for the TXA group and 1075.00±670.91mL for the control group (P=0.03) in the patients with clopidogrel exposure within 48 h before surgery. The average volume of blood loss was not different between two groups in the patients with clopidogrel exposure within 5 days before surgery and also transfusion rate. Conclusion: The result of this study shows that tranexamic acid reduced blood loss in the patients with clopidogrel exposure within 48 h before surgery. So, it is better that we use tranexamic acid before surgery in all patients.
Keywords :
Transfusion , Post-operative bleeding , Tranexamic acid , Clopidogrel , Coronary arteries bypass grafting
Journal title :
Astroparticle Physics
Serial Year :
2019
Link To Document :
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