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Title of article :
Effects of dietary supplementation of mannanoligosaccharide on virus shedding in avian influenza (H9N2) challenged broilers
Author/Authors :
Akhtar ، T. - University of Veterinary and Animal Sciences , Ara ، G. - University of Agriculture , Ali ، N. - University of Agriculture , ud Din Mufti ، F. - Quaid-i-Azam University , Imran Khan ، M. - University of Agriculture
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Abstract :
Avian influenza (AI) is a highly contagious disease causing significant economic losses worldwide. The aim of this study is to evaluate the effect of mannan-oligosaccharide (MOS) on tracheal and cloacal virus shedding in AI challenged broilers and contamination of environment with H9N2. A total of 300 1-day-old-broiler chicks were randomly divided into 3 groups (A, B and C) and supplemented 0.2, 0.5 and 0.0% MOS, respectively in NRC recommended diet for 36 days. On day 21 the groups were further split into two sub groups A+ve, A-ve, B+ve, B-ve, C+ve and C-ve with 5 replicates each. The positive groups were shifted to remote sheds and were challenged intranasally with 0.1 ml of reference virus (AIV; Pk-UDL/01/08 H9N2) with EID50 = 10^-6.66. Treatment reduces (P 0.05) cloacal virus shedding from day 24 to 26 and 28 to 32. Tracheal virus shedding was lower (P 0.05) on days 25-26 and 28-30 in treatment groups. Day 27 showed highest (P 0.05) virus shedding in all groups. However the reduction of viral shedding is faster in treatment groups and showed no virus shedding on day 32. Maternal antibody titer against AI showed a declining pattern but MOS influenced (P 0.05) the titer in treated groups. Hence the use of MOS may constitute a novel and effective plausible alternative that reduces the spread of disease by decreasing virus shedding and contamination of environment from AIV (H9N2) infection in poultry.
Keywords :
Avian influenza , Broiler , MOS , SAF , Mannan
Journal title :
Iranian Journal of Veterinary Research (IJVR)
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