Title of article :
Triggers, Bullets and Targets, Puzzle of Membranous Nephropathy
Ardalan, Mohammadreza Nephrology Department - Tabriz University of Medical sciences, Tabriz
Introduction: Idiopathic Membranous Nephropathy (MN) is a common cause of adult
nephrotic syndrome. Recently, M-type phospholipase A2 receptor (PLA2-R) has been discovered
as the main podocyte antigen in the pathogenesis of idiopathic MN.
Materials and Methods: In this mini review, the author searched English-language
MEDLINE for the terms “membranous nephropathy”, “rituximab”, and “phospholipase
A2 receptor” up to October 2011.
Results: In support of its earlier discovery, reports from China and Europe confirmed
the major pathogenic role of non-complement fixing IgG4 antibody against PLA2-R in
the pathogenesis of idiopathic MN. Antibodies against aldose reductase (AR) and manganese
superoxide dismutase (SOD2 ), and sub-epithelial deposition of cationic bovine
serum albumin (BSA) are also reported in rare occasions. It seems that Rituximab is a
good therapeutic choice for those patients who need immunosuppressive therapy.
Conclusions: Great discoveries in the diagnosis and treatment of idiopathic MN have
been performed but pathogenic mechanism and triggers for anti-PLA2-R production are
Glomerulonephritis , Membranous , Phospholipase A2 , Rituximab , 6B1 IgG4 Monoclonal Antibody
Journal title :