Record number :
2432708
Title of article :
Outcome of 121 patients with renal amyloid a amyloidosis
Author/Authors :
Ahbap, Elbis Department of Nephrology - Sisli Hamdiye Etfal Educational and Research Hospital - Şişli, Istanbul, Turkey , Kara, Ekrem Department of Nephrology - Sisli Hamdiye Etfal Educational and Research Hospital - Şişli, Istanbul, Turkey , Sahutoglu, Tuncay Department of Nephrology - Sisli Hamdiye Etfal Educational and Research Hospital - Şişli, Istanbul, Turkey , Basturk, Taner Department of Nephrology - Sisli Hamdiye Etfal Educational and Research Hospital - Şişli, Istanbul, Turkey , Koc, Yener Department of Nephrology - Sisli Hamdiye Etfal Educational and Research Hospital - Şişli, Istanbul, Turkey , Sakaci, Tamer Department of Nephrology - Sisli Hamdiye Etfal Educational and Research Hospital - Şişli, Istanbul, Turkey , Sevinc, Mustafa Department of Nephrology - Sisli Hamdiye Etfal Educational and Research Hospital - Şişli, Istanbul, Turkey , Akgol, Cuneyt Department of Nephrology - Sisli Hamdiye Etfal Educational and Research Hospital - Şişli, Istanbul, Turkey , Ucar, Zuhal Atan Department of Nephrology - Sisli Hamdiye Etfal Educational and Research Hospital - Şişli, Istanbul, Turkey , Kayalar, Arzu Ozdemir Department of Nephrology - Sisli Hamdiye Etfal Educational and Research Hospital - Şişli, Istanbul, Turkey , Bayraktar, Feyza Department of Nephrology - Sisli Hamdiye Etfal Educational and Research Hospital - Şişli, Istanbul, Turkey , Ozagari, Ayse Aysim Department of Nephrology - Sisli Hamdiye Etfal Educational and Research Hospital - Şişli, Istanbul, Turkey , Unsal, Abdulkadir Department of Nephrology - Sisli Hamdiye Etfal Educational and Research Hospital - Şişli, Istanbul, Turkey
Pages :
6
From page :
644
To page :
649
Abstract :
Background: Amyloid A (AA) amyloidosis is a multisystem, progressive and fatal disease. Renal involvement occurs early in the course of AA. We aimed to investigate the etiology, clinical and laboratory features, and outcome of patients with biopsy-proven renal AA amyloidosis. Materials and Methods: A total of 121 patients (male/female: 84/37, mean age 42.6 ± 14.4 years) were analyzed retrospectively between January of 2001 and May of 2013. Demographic, clinical and laboratory features and outcomes data were obtained from follow-up charts. Results: Familial Mediterranean fever (37.2%) and tuberculosis (24.8%) were the most frequent causes of amyloidosis. Mean serum creatinine and proteinuria at diagnosis were 2.3 ± 2.1 mg/dL and 6.7 ± 5.3 g/day, respectively. Sixty-eight (56.2%) patients were started dialysis treatment during the follow-up period. Mean duration of renal survival was 64.7 ± 6.3 months. Age, serum creatinine and albumin levels were found as predictors of end-stage renal disease. Fifty patients (%41.3) died during the follow-up period. Th e mean survival of patients was 88.7 ± 7.8 months (median: 63 ± 13.9). 1, 2 and 5 years survival rates of patients were 80.7%, 68.2% and 51.3%, respectively. Older age, male gender, lower levels of body mass index, estimated glomerular fi ltration rate, serum albumin, calcium, and higher levels of phosphor, intact parathyroid hormone and proteinuria were associated with a higher mortality. Higher serum creatinine, lower albumin, dialysis requirement and short time to dialysis were predictors of mortality. Conclusion: Th e outcome of patients with AA amyloidosis and renal involvement is poor, particularly in those who had massive proteinuria, severe hypoalbuminemia and dialysis requirement at the outset.
Keywords :
Amyloid A amyloidosis , dialysis , end-stage renal disease , survival
Journal title :
Astroparticle Physics
Serial Year :
2014
Link To Document :
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