Akhondi-Meybodi, Mohsen Associate Professor - Department of Internal Medicine - Subspecialty in Gastroenterology and Hepatology - ShahidSadoughi University of Medical Sciences, Yazd , Ghane, Marzieh Medical Student - Member of Student Research Committee - ShahidSadoughi University of Medical Sciences, Yazd , Akhondi-Meybodi, Sara Medical Student - Member of Student Research Committee - ShahidSadoughi University of Medical Sciences, Yazd , Dashti, Golnaz General Practitioner - ShahidSadoughi University of Medical Sciences, Yazd
BACKGROUND The number of patients with gastric cancer is growing worldwide. In Iran (in 2009) of 74067 new cases of cancer, 6886 were diagnosed as having gastric
cancer. This study was conducted to investigate 5-year survival rate for gastric
cancer in Yazd province, central Iran. METHODS In this descriptive study, the medical records of patients with gastric cancer were collected from the archives of Yazd hospitals from 2001 to 2008. The data gathered included age, sex, type of histopathology, site of involvement, cancer staging, and mode of treatment, which were analyzed using SPSS software version 11.5. To investigate the survival and the factors influencing the survival time of patients, which are the main objectives of this study, Kaplan-Meier method was used and Cox proportional hazards model was fitted to the data. To compare survival function in different subgroups, the log rank test or generalized Wilcoxon test was used. RESULTS 295 cases of gastric cancer were enrolled in the study. The mean age of the subjects was 59.3 ± 9 years. 5-year survival rate of the patients was calculated as 18% where the highest rate was 39% for the age group of 50-60 years and the lowest was 3% for the age group of above 80 years. 5-year survival rates in different groups were as follows: 32% in women, 13% in men; 16% in adenocarcinoma, 46% in other pathologies; 16% in gastric cardia involvement, 17% in antrum; 59% in stage 1, 31% in stage 2, 13% in stage 3, and 3% in stage 4. CONCLUSION The results of this study showed that age, stage of the cancer, mode of therapy, and type of histopathology affected the survival rate of gastric cancer. No significant association was found between the site of involvement and survival rate. In general, the survival rate for gastric cancer was low, which might be due to slow but steady progress of the disease and delayed referral of the patients.