Record number :
2393961
Title of article :
Arsenic trioxide induce apoptosis independent of TNFR-I and CD30 pathways in Acute promyelocytic leukemia patient with t(15;17) translocation.
Author/Authors :
Ardjmand، A.R نويسنده Correspondance: Hematology, Oncology & BMT research center, Shariati Hospital, Kargar Ave. 14114, Tehran, Iran Ardjmand, A.R , Alimoghadam، K نويسنده Hematology Oncology & B.M.T research center, Tehran University of medical science, Tehran, Iran Alimoghadam, K , Kaviani، S نويسنده Hematology Dep., Faculty of Medicine, Tarbiat Modares University, Tehran-Iran Kaviani, S , Ghavamzadeh، A نويسنده Hematology Oncology & B.M.T research center, Tehran University of medical science, Tehran, Iran Ghavamzadeh, A , Djahani، M نويسنده Hematology Oncology & B.M.T research center, Tehran University of medical science, Tehran, Iran Djahani, M , Moezzi، L نويسنده Hematology Oncology & B.M.T research center, Tehran University of medical science, Tehran, Iran Moezzi, L
Issue Information :
دوفصلنامه با شماره پیاپی 4 سال 2005
Pages :
5
From page :
27
To page :
31
Abstract :
Arsenic trioxide (ATO) has been reported to induce apoptosis in Leukemic cells of Acute Promyelo-cytic Leukemia (APL) patients through different pathways. However, the exact mechanism of ATO-induced apoptosis is not yet clear. Co stimulation of death receptors CD30 and tumor necrosis factor receptor type one (TNFR-I) is one of the postulated mechanisms.In the present study we aimed to evaluate their involvement in fresh Promyelocytic cells separated from bone marrow of APL patients. Immunomagnetic separated cells were treated up to 48 hr at clinically tolerable concentrations of ATO (0.5-2.0 µmol/l) and expression of TNFR-I and CD30 were evaluated within the apoptotic and live populations using a sensitive triple color flow cytometric method for measuring apoptosis in combina¬tion with dual color immunofluorescence. Our results suggest that the expression of TNFR-I and CD30 might not be related to  ATO-induced apoptotic cell death.
Journal title :
International Journal of Hematology-Oncology and Stem Cell Research (IJHOSCR)
Serial Year :
2005
Link To Document :
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