Title of article :
Study of Antibacterial Effect of Novel Thiazole, Imidazole, and Tetrahydropyrimidine Derivatives against Listeria Monocytogenes
قاسمي ، بهزاد نويسنده , , بيضايي، حميد نويسنده بيمارستان 522 ارتش تبريز , , هاشمي، هادي نويسنده ,
Issue Information :
فصلنامه با شماره پیاپی 51 سال 2015
Purpose: In this study, we have focused on antibacterial effect of newly synthesized thiazole,
imidazole, and tetrahydropyrimidine derivatives in Iran on listeria monocytogenes.
Materials and Methods: For evaluation of antibacterial effect, the disk diffusion method was
applied to measure the growth inhibition zone diameter and broth micro dilution was performed
to determine the minimum inhibitory concentration.
Results: Assessing the antibacterial effect showed that only thiazole derivative 6d had inhibitory
effect on listeria monocytogenes and the other thiazole, imidazole and tetrahydropyrimidine
derivatives lacked any inhibitory clue on this organism. The inhibitory effect of thiazole derivative
6d was shown by minimum inhibitory concentration = 64 and growth inhibition zone diameter
= 23 ± 0.1. In antibiogram test, also the most susceptibility was recorded for gentamicin and
penicillin with minimum inhibitory concentration = 1 ?g/mL.
Conclusion: The antibacterial effect of thiazole, imidazole and tetrahydropyrimidine derivatives
differs from each other and cross connections such as linkage of oxygen to thiazole ring in
derivative 6d, could reinforce this effect. By proving the in vitro antibacterial effect of the novel
thiazole derivative on listeria monocytogenes, to more recognize this compound, next step is
determining the toxicity and therapeutic effects in laboratory animals.
Journal title :
Annals of Military and Health Sciences Research