Record number :
2317521
Title of article :
Substantivity of chlorhexidine to human dentin
Author/Authors :
Carrilho، نويسنده , , Marcela R. and Carvalho، نويسنده , , Ricardo M. and Sousa، نويسنده , , Ethan N. and Nicolau، نويسنده , , José and Breschi، نويسنده , , Lorenzo and Mazzoni، نويسنده , , Annalisa and Tjنderhane، نويسنده , , Leo and Tay، نويسنده , , Franklin R. and Agee، نويسنده , , Kelli and Pashley، نويسنده , , David H.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Pages :
7
From page :
779
To page :
785
Abstract :
Objectives ter comprehend the role of CHX in the preservation of resin–dentin bonds, this study investigated the substantivity of CHX to human dentin. al and methods disks (n = 45) were obtained from the mid-coronal portion of human third molars. One-third of dentin disks were kept mineralized (MD), while the other two-thirds had one of the surfaces partially demineralized with 37% phosphoric acid for 15 s (PDD) or they were totally demineralized with 10% phosphoric acid (TDD). Disks of hydroxyapatite (HA) were also prepared. Specimens were treated with: (1) 10 μL of distilled water (controls), (2) 10 μL of 0.2% chlorhexidine diacetate (0.2% CHX) or (3) 10 μL of 2% chlorhexidine diacetate (2% CHX). Then, they were incubated in 1 mL of PBS (pH 7.4, 37 °C). Substantivity was evaluated as a function of the CHX-applied dose after: 0.5 h, 1 h, 3 h, 6 h, 24 h, 168 h (1 week), 672 h (4 weeks) and 1344 h (8 weeks) of incubation. CHX concentration in eluates was spectrophotometrically analyzed at 260 nm. s icant amounts of CHX remained retained in dentin substrates (MD, PPD or TDD), independent on the CHX-applied dose or time of incubation (p < 0.05). High amounts of retained CHX onto HA were observed only for specimens treated with the highest concentration of CHX (2%) (p < 0.05). sion tstanding substantivity of CHX to dentin and its reported effect on the inhibition of dentinal proteases may explain why CHX can prolong the durability of resin–dentin bonds.
Keywords :
Chlorhexidine , Binding , Dentin , substantivity
Journal title :
Dental Materials
Serial Year :
2010
Link To Document :
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