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Title of article :
Acetylthiocholine (ATC) – Cleaving cholinesterase (ChE) activity as a potential biomarker of pesticide exposure in the Manila clam, Ruditapes philippinarum, of Korea
Author/Authors :
Choi، نويسنده , , Jin Young and Yu، نويسنده , , Jun and Yang، نويسنده , , Dong Beom and Ra، نويسنده , , Kongtae and Kim، نويسنده , , Kyung Tae and Hong، نويسنده , , Gi Hoon and Shin، نويسنده , , Kyung Hoon، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Pages :
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Abstract :
The acetylthiocholine (ATC) – cleaving cholinesterase (ChE) activity in Manila clam, which is widely distributed throughout the coastal environment of Korea, was assayed as a potentially useful biomarker of organophosphorous pesticides (OPs). A clear dose–response relationship was determined between inhibited ChE in adductor muscle of clams and four OPs (methidathion, chlorpyrifos, diazinon, IBP) which are heavily used OPs in Korea. The measured EC50-24 h values of methidathion, chlorpyrifos, diazinon, and IBP for Ruditapes philippinarum were 7.16 μg l−1, 0.34 mg l−1, 3.01 mg l−1, and 3.41 mg l−1, respectively. In field studies, ChE activity in Manila clams collected from 23 stations in the mid-western coastal region demonstrated spatial variation with statistical differences. These results suggest that ChE activity in R. philippinarum is a potential biomarker for assessing organophosphorous pesticide contamination in coastal environments.
Keywords :
Biomarker , Cholinesterase , IBP , Manila clam , Chlorpyrifos , Organophosphorous pesticides (OPs) , Ruditapes philippinarum
Journal title :
Marine Environmental Research
Journal title :
Marine Environmental Research
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