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Title of article :
Expression of tumor necrosis factor-α in IgM+ B-cells from bovine leukemia virus-infected lymphocytotic sheep
Author/Authors :
Usui، نويسنده , , Tatsufumi and Konnai، نويسنده , , Satoru and Ohashi، نويسنده , , Kazuhiko and Onuma، نويسنده , , Misao، نويسنده ,
Issue Information :
سالنامه با شماره پیاپی سال 2006
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Abstract :
Tumor necrosis factor (TNF)-α is thought to be one of the cytokines that account for bovine leukemia virus (BLV)-induced B-cell lymphoproliferative disorder, however, information on TNF-α expression in B-cells is limited. In this study, the expression of TNF-α in IgM+ B-cells from BLV-infected sheep with or without lymphocytosis was determined. Freshly isolated IgM+ B-cells from three sheep with lymphocytosis constitutively transcribed TNF-α mRNA. Although TNF-α mRNA expression in IgM+ B-cells was transiently up-regulated after cell culture, TNF-α mRNA expression was markedly higher in lymphocytotic sheep when compared to that of non-lymphocytotic sheep or uninfected sheep. Expression of membrane-bound TNF-α on IgM+ B-cells was also augmented in lymphocytotic sheep. TNF-α expression in lymphocytotic sheep may support the proliferation of B-cells.
Keywords :
TNF-? , B-cell , BLV
Journal title :
Veterinary Immunology and Immunopathology
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