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Title of article :
Topical application of Pleurotus eryngii extracts inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice by the regulation of Th1/Th2 balance
Author/Authors :
Choi، نويسنده , , Jae Ho and Kim، نويسنده , , Hyung Gyun and Jin، نويسنده , , Sun Woo and Han، نويسنده , , Eun Hee and Khanal، نويسنده , , Tilak and Do، نويسنده , , Minh Truong and Hwang، نويسنده , , Yong Pil and Choi، نويسنده , , Jun Min and Chun، نويسنده , , Sung-Sik and Chung، نويسنده , , Young Chul and Jeong، نويسنده , , Tae Cheon and Jeong، نويسنده , , Hye Gwang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
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Abstract :
Pleurotus eryngii is a nutritional and medicinal food rich in polysaccharides that enhance the host immune system as a response to various diseases. The present study investigated the effects of P. eryngii extracts (PEE) on the progress of atopic dermatitis (AD)-like skin lesions in NC/Nga mice induced by 2,4-dinitrochlorobenzene (DNCB). We evaluated skin dermatitis severity, ear thickness, histopathological examination, and cytokines level in DNCB-applied mice treated with PEE. Continuous treatment of PEE inhibited the development of the AD-like skin lesions. PEE suppressed DNCB-induced dermatitis severity, serum level of IgE and thymus and activation-regulated chemokine (TARC), and mRNA expression of TNF-α, INF-γ, IL-4, IL-5, and IL-13 in mice. In addition, PEE reduced thickness of the dermis and dermal infiltration of inflammatory cells and mast cells in histopathological examination. These results indicate that PEE inhibits allergic contact dermatitis through the modulating of T helper (Th)1 and Th2 responses and diminishing the inflammatory cells and mast cells infiltration in the skin lesions in NC/Nga mice.
Keywords :
IGE , TARC , NC/Nga mice , Pleurotus eryngii , atopic dermatitis
Journal title :
Food and Chemical Toxicology
Journal title :
Food and Chemical Toxicology
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