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Title of article :
Inhibitory effect of Psidium guajava water extract in the development of 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice
Author/Authors :
Choi، نويسنده , , Jae Ho and Park، نويسنده , , Bong-Hwan and Kim، نويسنده , , Hyung Gyun and Hwang، نويسنده , , Yong Pil and Han، نويسنده , , Eun Hee and Jin، نويسنده , , Sun Woo and Seo، نويسنده , , Jong Kwon and Chung، نويسنده , , Young Chul and Jeong، نويسنده , , Hye Gwang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
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Abstract :
Atopic dermatitis (AD) is a chronic, relapsing, and inflammatory skin disease associated with eczematous symptoms and IgE hyperproduction. Psidium guajava is an important food crop and medicinal plant with anti-oxidant, anti-inflammatory, and anti-allergic activities, supporting its traditional uses. Our previous studies have shown that P. guajava extract inhibits Th2 chemokine expression by suppressing the activation of NF-κB and STAT1 co-stimulated with TNF-α and INF-γ. In this study, we investigated the inhibitory effect of P. guajava water extract (PGW) on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in NC/Nga mice. Treatment of cream containing PGW onto DNCB-induced AD-like skin lesions in NC/Nga mice ameliorated lesion intensity scores, levels of IgE, thymus and activation-regulated chemokine (TARC), TNF-α, and IL-4 in serum and ears. In contrast, PGW increased level of the immunosuppressive cytokine IL-10. Histological analyses demonstrated decreased thickening of the epidermis/dermis as well as dermal infiltration by inflammatory cells. These results suggest that cream containing PGW may be a potential therapeutic modality for AD and adjunctive agent to control pruritus in AD.
Keywords :
Psidium guajava , atopic dermatitis , IGE , TARC
Journal title :
Food and Chemical Toxicology
Journal title :
Food and Chemical Toxicology
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