Record number :
2121004
Title of article :
Low trans structured fat from flaxseed oil improves plasma and hepatic lipid metabolism in apo E−/− mice
Author/Authors :
Cho، نويسنده , , Yunyoung and Kwon، نويسنده , , Eun-Young and Kim، نويسنده , , Hye Jin and Park، نويسنده , , Yong-Bok and Lee، نويسنده , , Ki-Teak and Park، نويسنده , , TaeSun and Choi، نويسنده , , Myung-Sook، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
6
From page :
1550
To page :
1555
Abstract :
The objective of this study was to explicate the effects of feeding low trans structured fat from flaxseed oil (LF) on plasma and hepatic lipid metabolism involved in apo E−/− mice. The animals were fed a commercial shortening (CS), commercial low trans fat (CL) and LF diet based on AIN-76 diet (10% fat) for 12 weeks. LF supplementation exerted a significant suppression in hepatic lipid accumulation with the concomitant decrease in liver weight. The LF significantly lowered plasma total cholesterol and free fatty acid whereas it significantly increased HDL-C concentration and the HDL-C/total-C ratio compared to the CS group. Reduction of hepatic lipid levels in the LF group was related with the suppression of hepatic enzyme activities for fatty acid and triglyceride synthesis, and cholesterol regulating enzyme activity compared to the CS and CL groups. Accordingly, low trans structured fat from flaxseed oil is highly effective for improving hyperlipidemia and hepatic lipid accumulation in apo E−/− mice.
Keywords :
Hyperlipidemia , n  , 3 fatty acid , Flaxseed oil , ?  , Apo E?/? mice , Trans fatty acid
Journal title :
Food and Chemical Toxicology
Journal title :
Food and Chemical Toxicology
Serial Year :
2009
Link To Document :
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